Recombinant human Siglec-3/CD33 protein
€0.00
In stock
SKU
ATGP2584
Description
CD33 is putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. This protein induces apoptosis in acute myeloid leukemia (in vitro). Recombinant human CD33 protein, fused to His-tag at N-terminus, was expressed in E. coli.Alternative Names
SIGLEC-3, SIGLEC3, Sialic acid-binding Ig-like lectin 3, p67, Myeloid cell surface antigen CD33 isoform 1, Myeloid cell surface antigen CD33, FLJ00391, CD33 molecule, CD33Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
CD33 is putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. This protein induces apoptosis in acute myeloid leukemia (in vitro). Recombinant human CD33 protein, fused to His-tag at N-terminus, was expressed in E. coli.Alternative Names
SIGLEC-3, SIGLEC3, Sialic acid-binding Ig-like lectin 3, p67, Myeloid cell surface antigen CD33 isoform 1, Myeloid cell surface antigen CD33, FLJ00391, CD33 molecule, CD33Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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