Recombinant mouse IL-3R alpha/IL3RA protein
€0.00
In stock
SKU
ATGP4091
Description
IL-3R alpha/CD123, also known as interleukin 3 receptor subunit alpha, is a member of the type 1 cytokine receptor family and type 5 subfamily. It is expressed on multiple cell types, including endothelial cells, monocytes, eosinophils, basophils plus mast cells, and plasmacytoid CD4+ T cells. It serves as a low affinity binding protein for monomeric IL‑3. The IL‑3 and IL‑3 R alpha complex likely interacts with a preformed signaling homodimer comprised of either beta IL-3 or beta c chains. The extracellular domain of mouse IL‑3 R alpha/CD123 shares only 44% and 29% aa sequence identity with rat and human IL‑3 R alpha, respectively. Nevertheless, human IL‑3 is reported to be active on the mouse receptor complex that is expressed on select cell types. Also, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recombinant mouse IL-3R alpha/CD123, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, Interleukin-3 receptor class II alpha chain, L3RA, CD123, hIL-3Ra, IL3R, SUT-1Concentration
0.25mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
IL-3R alpha/CD123, also known as interleukin 3 receptor subunit alpha, is a member of the type 1 cytokine receptor family and type 5 subfamily. It is expressed on multiple cell types, including endothelial cells, monocytes, eosinophils, basophils plus mast cells, and plasmacytoid CD4+ T cells. It serves as a low affinity binding protein for monomeric IL‑3. The IL‑3 and IL‑3 R alpha complex likely interacts with a preformed signaling homodimer comprised of either beta IL-3 or beta c chains. The extracellular domain of mouse IL‑3 R alpha/CD123 shares only 44% and 29% aa sequence identity with rat and human IL‑3 R alpha, respectively. Nevertheless, human IL‑3 is reported to be active on the mouse receptor complex that is expressed on select cell types. Also, the specific alpha subunit of the interleukin 3 receptor is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recombinant mouse IL-3R alpha/CD123, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, Interleukin-3 receptor class II alpha chain, L3RA, CD123, hIL-3Ra, IL3R, SUT-1Concentration
0.25mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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