Recombinant mouse LRIG1 protein
€0.00
In stock
SKU
ATGP3937
Description
LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1, D6Bwg0781e, ImgConcentration
0.5mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1, D6Bwg0781e, ImgConcentration
0.5mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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