Recombinant mouse TIM-3/HAVCR2 protein
€0.00
In stock
SKU
ATGP3992
Description
TIM-3, also known as HAVCR2(epatitis A virus cellular receptor 2), belongs to TIM family cell surface receptor proteins.TIM-3 is up‑regulated on several populations of activated myeloid cells and T cells. It is an immune checkpoint and together with other inhibitory receptors including PD-1and LAG3 mediate the CD8+ T-cell exhaustion. Also, it is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. Recombinant mouse TIM-3, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD366Concentration
0.5mg/ml (determined by Absorbance at 280nm)Concentration
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
TIM-3, also known as HAVCR2(epatitis A virus cellular receptor 2), belongs to TIM family cell surface receptor proteins.TIM-3 is up‑regulated on several populations of activated myeloid cells and T cells. It is an immune checkpoint and together with other inhibitory receptors including PD-1and LAG3 mediate the CD8+ T-cell exhaustion. Also, it is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. Recombinant mouse TIM-3, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD366Concentration
0.5mg/ml (determined by Absorbance at 280nm)Concentration
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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