RELA antibody (clone 8G3), anti-human
€435.00
In stock
SKU
AC-AT3616a
Catalog Number: AC-AT3616a
Size: 100 µg
Isotype: mouse IgG1 Lambda
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Lambda
Applications: WB, IF, E
Request Information AC-AT3616a">Request Information
Background:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Other Names:
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Antigen Type:
Recombinant Protein
Gene Name: RELA
Gene ID: 5970
NCBI Accession: NP_001138610.1;NP_001230913.1;NP_068810.3
Primary Accession: Q04206
Other Accession: NM_021975
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Other Names:
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Antigen Type:
Recombinant Protein
Gene Name: RELA
Gene ID: 5970
NCBI Accession: NP_001138610.1;NP_001230913.1;NP_068810.3
Primary Accession: Q04206
Other Accession: NM_021975
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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