RELA (phospho-S276) polyclonal, anti-human, mouse, rat

Background:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Synonyms: NFKB3, p65

Cellular Location: Cytoplasm Nucleus

Immunogen:
A phospho specific peptide corresponding to residues surrounding S276 of human RELA

Gene Symbol: Phospho-RELA-S276

Gene ID: 5970

Swiss prot: Q04206

Calculated MW: 60kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100, IF 1:20-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.