REN antibody (clone 2H2), anti-human

Background:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

Other Names:
Renin, Angiotensinogenase, REN

Antigen Type:
Recombinant Protein

Gene Name: REN
Gene ID: 5972
NCBI Accession: NP_000528.1
Primary Accession: P00797
Other Accession: BC047752
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .