Renin (L238) polyclonal, anti-human
€305.00
In stock
SKU
BS3925
Background:
Renin is a highly specific endopeptidase that mediates the cleavage of the circulating substrate angiotensinogen to yield Angiotensin I. Angiotensin-converting enzyme I (ACE) then completes the conversion from Angiotensin I to Angiotensin II which is significant in the regulation of electrolyte balance and blood pressure. Sympathetic stimulation (β1-adrenergic receptors), renal artery hypotension and decreases in sodium delivery to the distal tubules of the kidney signal the release of Renin. The Renin-Angiotensin system (RAS) is essential for regulating blood volume, arterial pressure and normal cardiac and vascular function. Renin is synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus (JGA) of the kidney. Expression of Renin in other tissues, including brain, has been verified although the homeostatic role it may play is yet to be firmly established.
Alternative Name:
Angiotensin forming enzyme, Angiotensin forming enzyme precursor, Angiotensinogenase, Angiotensinogenase precursor, FLJ10761, HNFJ2, REN, Ren1, RENI, Renin, Renin precursor renal
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Renin (L238) polyclonal antibody detects endogenous levels of Renin protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 211-260 of Human Renin.
MW: ~ 45 kDa
Swis Prot.: P00797
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Renin is a highly specific endopeptidase that mediates the cleavage of the circulating substrate angiotensinogen to yield Angiotensin I. Angiotensin-converting enzyme I (ACE) then completes the conversion from Angiotensin I to Angiotensin II which is significant in the regulation of electrolyte balance and blood pressure. Sympathetic stimulation (β1-adrenergic receptors), renal artery hypotension and decreases in sodium delivery to the distal tubules of the kidney signal the release of Renin. The Renin-Angiotensin system (RAS) is essential for regulating blood volume, arterial pressure and normal cardiac and vascular function. Renin is synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus (JGA) of the kidney. Expression of Renin in other tissues, including brain, has been verified although the homeostatic role it may play is yet to be firmly established.
Alternative Name:
Angiotensin forming enzyme, Angiotensin forming enzyme precursor, Angiotensinogenase, Angiotensinogenase precursor, FLJ10761, HNFJ2, REN, Ren1, RENI, Renin, Renin precursor renal
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: Renin (L238) polyclonal antibody detects endogenous levels of Renin protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 211-260 of Human Renin.
MW: ~ 45 kDa
Swis Prot.: P00797
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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