Ret (phospho-Y1062) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4757
Background:
The Ret gene products include two glycosylated proteins and, in tunicamycin treated cells, a non-glycosylated protein consistent with the predicted Ret molecular weight based on sequence analysis. Tumor-specific rearrangements of the Ret proto-oncogene have been identified in papillary thyroid carcinomas leading to the formation of different transforming fusion proteins sharing the tyrosine kinase domain of Ret. In contrast to the Ret proto-oncogene, the rearranged forms are constitutively phosphorylated on tyrosine and are translocated from the membrane to the cytoplasm.
Alternative Name:
Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, RET, CDHF12, CDHR16, PTC, RET51
Application Dilution: IHC: 1:50~1:200
Specificity: p-Ret (Y1062) polyclonal antibody detects endogenous levels of Ret protein only when phosphorylated at Tyr1062.
Immunogen:
Synthetic phosphopeptide derived from human Ret around the phosphorylation site of Tyrosine 1062.
MW: ~ 124 kDa
Swis Prot.: P07949
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Ret gene products include two glycosylated proteins and, in tunicamycin treated cells, a non-glycosylated protein consistent with the predicted Ret molecular weight based on sequence analysis. Tumor-specific rearrangements of the Ret proto-oncogene have been identified in papillary thyroid carcinomas leading to the formation of different transforming fusion proteins sharing the tyrosine kinase domain of Ret. In contrast to the Ret proto-oncogene, the rearranged forms are constitutively phosphorylated on tyrosine and are translocated from the membrane to the cytoplasm.
Alternative Name:
Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, RET, CDHF12, CDHR16, PTC, RET51
Application Dilution: IHC: 1:50~1:200
Specificity: p-Ret (Y1062) polyclonal antibody detects endogenous levels of Ret protein only when phosphorylated at Tyr1062.
Immunogen:
Synthetic phosphopeptide derived from human Ret around the phosphorylation site of Tyrosine 1062.
MW: ~ 124 kDa
Swis Prot.: P07949
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review