RFX5 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP14004c
Background:
A lack of MHC-II expression results in a severeimmunodeficiency syndrome called MHC-II deficiency, or the barelymphocyte syndrome (BLS; MIM 209920). At least 4 complementationgroups have been identified in B-cell lines established frompatients with BLS. The molecular defects in complementation groupsB, C, and D all lead to a deficiency in RFX, a nuclear proteincomplex that binds to the X box of MHC-II promoters. The lack ofRFX binding activity in complementation group C results frommutations in the RFX5 gene encoding the 75-kD subunit of RFX(Steimle et al., 1995). RFX5 is the fifth member of the growingfamily of DNA-binding proteins sharing a novel and highlycharacteristic DNA-binding domain called the RFX motif. Multiplealternatively spliced transcript variants have been found but thefull-length natures of only two have been determined. [provided byRefSeq].
Other Names:
DNA-binding protein RFX5, Regulatory factor X 5, RFX5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14004c was selected from the Center region of RFX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RFX5
Gene ID: 5993
Primary Accession: P48382
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
A lack of MHC-II expression results in a severeimmunodeficiency syndrome called MHC-II deficiency, or the barelymphocyte syndrome (BLS; MIM 209920). At least 4 complementationgroups have been identified in B-cell lines established frompatients with BLS. The molecular defects in complementation groupsB, C, and D all lead to a deficiency in RFX, a nuclear proteincomplex that binds to the X box of MHC-II promoters. The lack ofRFX binding activity in complementation group C results frommutations in the RFX5 gene encoding the 75-kD subunit of RFX(Steimle et al., 1995). RFX5 is the fifth member of the growingfamily of DNA-binding proteins sharing a novel and highlycharacteristic DNA-binding domain called the RFX motif. Multiplealternatively spliced transcript variants have been found but thefull-length natures of only two have been determined. [provided byRefSeq].
Other Names:
DNA-binding protein RFX5, Regulatory factor X 5, RFX5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14004c was selected from the Center region of RFX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RFX5
Gene ID: 5993
Primary Accession: P48382
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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