RGDS Peptide
€235.00
In stock
SKU
350365
Protein Family: CAM Ligands
Pathway and Disease: Cancers, Cell Growth and Death, Cell Motility, Infectious Diseases, Signaling Molecules and Interaction
Alternate Names: Fibronectin; RGDS; Arg-Gly-Asp-Ser
Accession No.: P02751
Description:
The RGD peptide is the binding motif of fibronectin to cell adhesion molecules. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts to fibronectin. The free RGDS peptide inhibits attachment of cells to fibronectin-coated substrates. The RGDS sequence is also a target for infectious agents (Treponema's syphilis, Mycobacterium's tuberculosis). RGDS can also block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes.
Format:
Each vial contains 10 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 433.4 g/mol
Sequence:
H-Arg-Gly-Asp-Ser-OH or H-RGDS-OH
Composition:
C15H27N7O8
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Cancers, Cell Growth and Death, Cell Motility, Infectious Diseases, Signaling Molecules and Interaction
Alternate Names: Fibronectin; RGDS; Arg-Gly-Asp-Ser
Accession No.: P02751
Description:
The RGD peptide is the binding motif of fibronectin to cell adhesion molecules. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts to fibronectin. The free RGDS peptide inhibits attachment of cells to fibronectin-coated substrates. The RGDS sequence is also a target for infectious agents (Treponema's syphilis, Mycobacterium's tuberculosis). RGDS can also block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes.
Format:
Each vial contains 10 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 433.4 g/mol
Sequence:
H-Arg-Gly-Asp-Ser-OH or H-RGDS-OH
Composition:
C15H27N7O8
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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