RGS17 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60229
Background:
The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. The human gene that encodes RGS17 (regulator of G protein signaling 17, RGS17) contains 4 exons, spans more than 33 kb and maps to chromosome 6q25.3; the mouse Rgs17 gene maps to chromosome 10 as determined by interspecific backcross mapping. RGS17 is a member of the RZ/A protein family. RZ/A proteins have a simple structure that consists of a conserved amino-terminal cysteine string motif, RGS box and short carboxyl-terminal, which confer GAP activity and the ability to undergo covalent modification and associate with other proteins (at their amino-termini).
Alternative Name:
Regulator of G-protein signaling 17, RGS17
Application Dilution: WB: 1:500~1:1000
Specificity: RGS17 polyclonal antibody detects endogenous levels of RGS17 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RGS17.
MW: ~ 18 kDa
Swis Prot.: Q9UGC6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. The human gene that encodes RGS17 (regulator of G protein signaling 17, RGS17) contains 4 exons, spans more than 33 kb and maps to chromosome 6q25.3; the mouse Rgs17 gene maps to chromosome 10 as determined by interspecific backcross mapping. RGS17 is a member of the RZ/A protein family. RZ/A proteins have a simple structure that consists of a conserved amino-terminal cysteine string motif, RGS box and short carboxyl-terminal, which confer GAP activity and the ability to undergo covalent modification and associate with other proteins (at their amino-termini).
Alternative Name:
Regulator of G-protein signaling 17, RGS17
Application Dilution: WB: 1:500~1:1000
Specificity: RGS17 polyclonal antibody detects endogenous levels of RGS17 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RGS17.
MW: ~ 18 kDa
Swis Prot.: Q9UGC6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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