RGS5 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5897
Background:
Regulators of G protein signaling (RGS proteins) are a family of highly diverse, multifunctional signaling proteins that share a conserved 120 amino acid domain (RGS domain). RGS domains bind directly to activated Gα subunits and act as GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both Gα-GTP and Gβγ. RGS proteins shorten the lifetime of activated G proteins. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke.
Alternative Name:
Regulator of G-protein signaling 5, RGS-5
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: RGS5 polyclonal antibody detects endogenous levels of RGS5 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 130-175 of Human RGS5.
MW: ~ 25 kDa
Swis Prot.: O15539
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Regulators of G protein signaling (RGS proteins) are a family of highly diverse, multifunctional signaling proteins that share a conserved 120 amino acid domain (RGS domain). RGS domains bind directly to activated Gα subunits and act as GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both Gα-GTP and Gβγ. RGS proteins shorten the lifetime of activated G proteins. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke.
Alternative Name:
Regulator of G-protein signaling 5, RGS-5
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: RGS5 polyclonal antibody detects endogenous levels of RGS5 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 130-175 of Human RGS5.
MW: ~ 25 kDa
Swis Prot.: O15539
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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