RHEB polyclonal, anti-human, mouse

Background:
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.Farnesylation is important for efficiently activating mTORC1-mediated signaling. Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.

Alternative Name:
GTP binding protein Rheb, GTP-binding protein Rheb, MGC111559, Ras homolog enriched in brain 2, Ras homolog enriched in brain, RHEB 2, Rheb, RHEB, RHEB2,

Application Dilution: WB: 1:500 - 1:2000

Specificity: RHEB polyclonal antibody detects endogenous levels of RHEB protein.

Immunogen:
Recombinant full length Human RHEB.

MW: ~ 20 kDa

Swis Prot.: Q15382

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.