RIG-I (clone Alme-1) biotin, anti-human, mouse

Decription:
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

Synonyms: RIG-1, Retinoic Acid-inducible Gene 1 Protein, DEAD-box Protein 58, Probable ATP-dependent RNA Helicase DDX58

Clone: Alme-1

Isotype: Mouse IgG1

Immunogen: Recombinant human RIG-I (aa 201-713).

Reactivity: human, mouse

Specificity: Recognizes human and mouse RIG-I.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
Immunohistochemistry: (paraffin sections) Immunoprecipitation: (1:200)
Western blot: (1:1'000)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)