RIPK3 monoclonal, anti-human
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In stock
SKU
AC-AM8682b
Catalog Number: AC-AM8682b
Size: 50 µl, 200 µl
Isotype: mouse IgG1,κ
Clone Name: 2013CT892.86.49
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG1,κ
Clone Name: 2013CT892.86.49
Applications: WB
Datasheet
Request Information
Background:
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Other Names:
Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3
Target/Specificity:
This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.
Antigen Type: Synthesized Peptide
Gene Name: RIPK3 (HGNC:10021)
Gene ID: 11035
Primary Accession: Q9Y572
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Other Names:
Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3
Target/Specificity:
This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.
Antigen Type: Synthesized Peptide
Gene Name: RIPK3 (HGNC:10021)
Gene ID: 11035
Primary Accession: Q9Y572
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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