RKHD3 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP1959c
Background:
RKHD3, also known as MEX3B is a member of a family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including RKHD3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. MEX3A and MEX3B, but not MEX3C,colocalize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover. MEX3 proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms.
Other Names:
RNA-binding protein MEX3B, RING finger and KH domain-containing protein 3, RING finger protein 195, MEX3B, KIAA2009, RKHD3, RNF195
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1959c was selected from the Center region of human RKHD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MEX3B
Gene ID: 84206
Primary Accession: Q6ZN04
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
RKHD3, also known as MEX3B is a member of a family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including RKHD3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. MEX3A and MEX3B, but not MEX3C,colocalize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover. MEX3 proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms.
Other Names:
RNA-binding protein MEX3B, RING finger and KH domain-containing protein 3, RING finger protein 195, MEX3B, KIAA2009, RKHD3, RNF195
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1959c was selected from the Center region of human RKHD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MEX3B
Gene ID: 84206
Primary Accession: Q6ZN04
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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