RLN3 polyclonal, anti-human, mouse
€305.00
In stock
SKU
BS60503
Background:
Relaxin 3 is part of the Relaxin-like peptide family that plays an important neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in long-term control of food intake.
Alternative Name:
Relaxin-3, Insulin-like peptide INSL7, Insulin-like peptide 7, Prorelaxin H3, RLN3, INSL7, RXN3, ZINS4, UNQ6188, PRO20213
Application Dilution: WB: 1:500~1:1000
Specificity: RLN3 polyclonal antibody detects endogenous levels of RLN3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RLN3.
MW: ~ 15 kDa
Swis Prot.: Q8WXF3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Relaxin 3 is part of the Relaxin-like peptide family that plays an important neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in long-term control of food intake.
Alternative Name:
Relaxin-3, Insulin-like peptide INSL7, Insulin-like peptide 7, Prorelaxin H3, RLN3, INSL7, RXN3, ZINS4, UNQ6188, PRO20213
Application Dilution: WB: 1:500~1:1000
Specificity: RLN3 polyclonal antibody detects endogenous levels of RLN3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RLN3.
MW: ~ 15 kDa
Swis Prot.: Q8WXF3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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