RNase L polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71344
Background:
RNase L encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. Interferon treatment enhances levels of both RNase L and a group of synthetases that produce 5-prime-triphosphorylated, 2-prime,5-prime-oligoadenylates (2-5A) from ATP. The role of the 2-5A system in the control of viral and cellular growth suggests that defects in the 2-5A-dependent RNase gene could result in reduced immunity to viral infections and cancer.
Alternative Name:
2-5A-dependent Rnase, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: RNase L polyclonal antibody detects endogenous levels of RNase L protein.
Immunogen:
Recombinant protein of human RNASEL.
MW: ~ 84 kDa
Swis Prot.: Q05823
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
RNase L encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. Interferon treatment enhances levels of both RNase L and a group of synthetases that produce 5-prime-triphosphorylated, 2-prime,5-prime-oligoadenylates (2-5A) from ATP. The role of the 2-5A system in the control of viral and cellular growth suggests that defects in the 2-5A-dependent RNase gene could result in reduced immunity to viral infections and cancer.
Alternative Name:
2-5A-dependent Rnase, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: RNase L polyclonal antibody detects endogenous levels of RNase L protein.
Immunogen:
Recombinant protein of human RNASEL.
MW: ~ 84 kDa
Swis Prot.: Q05823
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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