RNASEH2A antibody (clone 3G5-F5), anti-human
€435.00
In stock
SKU
AC-AT3653a
Catalog Number: AC-AT3653a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
Request Information AC-AT3653a">Request Information
Background:
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Other Names:
Ribonuclease H2 subunit A, RNase H2 subunit A, Aicardi-Goutieres syndrome 4 protein, AGS4, RNase H(35), Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A, RNASEH2A, RNASEHI, RNHIA
Antigen Type:
Recombinant Protein
Gene Name: RNASEH2A
Gene ID: 10535
NCBI Accession: NP_006388.2
Primary Accession: O75792
Other Accession: BC011748
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Other Names:
Ribonuclease H2 subunit A, RNase H2 subunit A, Aicardi-Goutieres syndrome 4 protein, AGS4, RNase H(35), Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A, RNASEH2A, RNASEHI, RNHIA
Antigen Type:
Recombinant Protein
Gene Name: RNASEH2A
Gene ID: 10535
NCBI Accession: NP_006388.2
Primary Accession: O75792
Other Accession: BC011748
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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