RNF126 Blocking Peptide (Center)
€363.00
In stock
SKU
AC-BP21884c
Background:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
Other Names:
E3 ubiquitin-protein ligase RNF126, 632-, RING finger protein 126 {ECO:0000312|HGNC:HGNC:21151}, RNF126 (HGNC:21151)
Target/Specificity:
The synthetic peptide sequence is selected from aa 104-115 of HUMAN RNF126 (HGNC:21151)
Gene Name: RNF126 {ECO:0000303|PubMed:23026136, ECO:0000312|HGNC:HGNC:21151}
Gene ID: 55658
Primary Accession: Q9BV68
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
Other Names:
E3 ubiquitin-protein ligase RNF126, 632-, RING finger protein 126 {ECO:0000312|HGNC:HGNC:21151}, RNF126 (HGNC:21151)
Target/Specificity:
The synthetic peptide sequence is selected from aa 104-115 of HUMAN RNF126 (HGNC:21151)
Gene Name: RNF126 {ECO:0000303|PubMed:23026136, ECO:0000312|HGNC:HGNC:21151}
Gene ID: 55658
Primary Accession: Q9BV68
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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