ROBO2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61260
Background:
Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior. In the vertebrate spinal cord, the insect ventral nerve cord and C. elegans, midline cells produce guidance cues such as Nectins and Slit, which act as attractants and repellents, respectively. These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway. One such gatekeeper, robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals. Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion. Non-crossing axons express high levels of robo, whereas crossing axons express low levels of robo before reaching the midline and high levels after they cross. Robo1 and robo2 are two human homologs of the Drosophila protein Roundabout. Robo1 is also homologous to the C. elegans gene sax3, whereas robo2 is homologous to the zebrafish gene astray.
Alternative Name:
Roundabout homolog 2, ROBO2, KIAA1568
Application Dilution: WB: 1:500~1:1000
Specificity: ROBO2 polyclonal antibody detects endogenous levels of ROBO2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ROBO2.
MW: ~ 151 kDa
Swis Prot.: Q9HCK4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior. In the vertebrate spinal cord, the insect ventral nerve cord and C. elegans, midline cells produce guidance cues such as Nectins and Slit, which act as attractants and repellents, respectively. These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway. One such gatekeeper, robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals. Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion. Non-crossing axons express high levels of robo, whereas crossing axons express low levels of robo before reaching the midline and high levels after they cross. Robo1 and robo2 are two human homologs of the Drosophila protein Roundabout. Robo1 is also homologous to the C. elegans gene sax3, whereas robo2 is homologous to the zebrafish gene astray.
Alternative Name:
Roundabout homolog 2, ROBO2, KIAA1568
Application Dilution: WB: 1:500~1:1000
Specificity: ROBO2 polyclonal antibody detects endogenous levels of ROBO2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ROBO2.
MW: ~ 151 kDa
Swis Prot.: Q9HCK4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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