ROCK1 (clone 12M03), anti-human antibody
€325.00
In stock
SKU
AC-ABV10401-100
Catalog Number: AC-ABV10401-100
Size: 100 µg
Host: Mouse IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Mouse IgG
Applications: WB
Datasheet
Request Information
Background:
ROCK-1 (Rho-associated coiled coil-containing protein kinase 1) has been found to be a new caspase-3 substrate. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain. During apoptosis, ROCK-1 is cleaved by caspase-3 at the conserved DETD1113/G sequence and its C-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3 mediated cleavage and activation of ROCK-1 induces phosphorylation of MLC and membrane blebbing, the early events in the execution phase of apoptosis.
Other Names:
ROCK1 , P160ROCK , MGC131603 , MGC43611 , p160ROCK , EC 2.7.11.1
Primary Accession: Q13464
Gene Name: ROCK1
Gene ID: 6093
Concentration (mg/ml): 0.5 mg/ml
ROCK-1 (Rho-associated coiled coil-containing protein kinase 1) has been found to be a new caspase-3 substrate. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain. During apoptosis, ROCK-1 is cleaved by caspase-3 at the conserved DETD1113/G sequence and its C-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3 mediated cleavage and activation of ROCK-1 induces phosphorylation of MLC and membrane blebbing, the early events in the execution phase of apoptosis.
Other Names:
ROCK1 , P160ROCK , MGC131603 , MGC43611 , p160ROCK , EC 2.7.11.1
Primary Accession: Q13464
Gene Name: ROCK1
Gene ID: 6093
Concentration (mg/ml): 0.5 mg/ml
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