ROS (phospho-Y2114) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64028
Background:
LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B-lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occuring in many non-Hodgkin’s lymphomas. The c-ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
Alternative Name:
Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS
Application Dilution: WB: 1:500~1:1000
Specificity: p-ROS (Y2114) polyclonal antibody detects endogenous levels of human ROS only when phosphorylated at Tyr2114.
Immunogen:
Synthetic phosphopeptide derived from human ROS around the phosphorylation site of Tyrosine 2114.
MW: ~ 264 kDa
Swis Prot.: P08922
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B-lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occuring in many non-Hodgkin’s lymphomas. The c-ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
Alternative Name:
Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS
Application Dilution: WB: 1:500~1:1000
Specificity: p-ROS (Y2114) polyclonal antibody detects endogenous levels of human ROS only when phosphorylated at Tyr2114.
Immunogen:
Synthetic phosphopeptide derived from human ROS around the phosphorylation site of Tyrosine 2114.
MW: ~ 264 kDa
Swis Prot.: P08922
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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