RPL6 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8076
Background:
Mammalian ribosomal proteins are encoded by multigene families that consist of processed pseudogenes and one functional intron-containing gene within their coding regions. Ribosomal Protein L6, also known as RPL6, TAXREB107 or TXREB1, is a 288 amino acid component of the large ribosomal 60S subunit. Localized to the cytoplasm, Ribosomal Protein L6 binds specifically to domain C of the tax-responsive element (FOXN2) of human T-cell leukemia virus type 1, thereby regulating tax-mediated transcriptional activation. Ribosomal Protein L6 is upregulated in multi-drug resistant (MDR) gastric cancer cells and is implicated in Noonan syndrome, a congenital genetic condition characterized by impaired blood clotting, short stature and indentation of the chest. Two isoforms exist due to alternative splicing events.
Alternative Name:
60S ribosomal protein L6, Neoplasm-related protein C140, Tax-responsive enhancer element-binding protein 107, TaxREB107, RPL6, TXREB1
Application Dilution: WB: 1:500 - 1:2000
Specificity: RPL6 polyclonal antibody detects endogenous levels of RPL6 protein.
Immunogen:
Recombinant full length Human RPL6.
MW: ~ 33 kDa
Swis Prot.: Q02878
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Mammalian ribosomal proteins are encoded by multigene families that consist of processed pseudogenes and one functional intron-containing gene within their coding regions. Ribosomal Protein L6, also known as RPL6, TAXREB107 or TXREB1, is a 288 amino acid component of the large ribosomal 60S subunit. Localized to the cytoplasm, Ribosomal Protein L6 binds specifically to domain C of the tax-responsive element (FOXN2) of human T-cell leukemia virus type 1, thereby regulating tax-mediated transcriptional activation. Ribosomal Protein L6 is upregulated in multi-drug resistant (MDR) gastric cancer cells and is implicated in Noonan syndrome, a congenital genetic condition characterized by impaired blood clotting, short stature and indentation of the chest. Two isoforms exist due to alternative splicing events.
Alternative Name:
60S ribosomal protein L6, Neoplasm-related protein C140, Tax-responsive enhancer element-binding protein 107, TaxREB107, RPL6, TXREB1
Application Dilution: WB: 1:500 - 1:2000
Specificity: RPL6 polyclonal antibody detects endogenous levels of RPL6 protein.
Immunogen:
Recombinant full length Human RPL6.
MW: ~ 33 kDa
Swis Prot.: Q02878
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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