RPP30 polyclonal, anti-human
€388.00
In stock
SKU
BS71248
Background:
RNase P, which consists of a complex of an RNA species (H1 RNA), POP1 (Processing of Precursor 1), POP5 (Processing of Precursor 5), and at least seven Rpps (including Rpp14, Rpp29, Rpp30 and Rpp38), removes the 5' leader sequences from precursor tRNA molecules. The structurally related RNase MRP plays an essential role in the formation of the 5' end of 5.8S rRNA. Both RNase P and RNase MRP are associated with Th/To ribonucleoproteins; Rpp30 and Rpp38 have specifically been implicated as Th autoantigens which contribute to the autoimmune disease systemic sclerosis.
Alternative Name:
RNASEP2, Ribonuclease P protein subunit p30, RNaseP protein p30, RNase P subunit 2
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: RPP30 polyclonal antibody detects endogenous levels of RPP30 protein.
Immunogen:
Recombinant protein of human RPP30.
MW: ~ 29 kDa
Swis Prot.: P78346
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
RNase P, which consists of a complex of an RNA species (H1 RNA), POP1 (Processing of Precursor 1), POP5 (Processing of Precursor 5), and at least seven Rpps (including Rpp14, Rpp29, Rpp30 and Rpp38), removes the 5' leader sequences from precursor tRNA molecules. The structurally related RNase MRP plays an essential role in the formation of the 5' end of 5.8S rRNA. Both RNase P and RNase MRP are associated with Th/To ribonucleoproteins; Rpp30 and Rpp38 have specifically been implicated as Th autoantigens which contribute to the autoimmune disease systemic sclerosis.
Alternative Name:
RNASEP2, Ribonuclease P protein subunit p30, RNaseP protein p30, RNase P subunit 2
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: RPP30 polyclonal antibody detects endogenous levels of RPP30 protein.
Immunogen:
Recombinant protein of human RPP30.
MW: ~ 29 kDa
Swis Prot.: P78346
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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