Rrn3 (phospho-S649) polyclonal antibody, anti-human

Background:
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.

Alternative Name:
RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA, RRN3, TIFIA

Application Dilution:
WB: 1:500~1:1000

Specificity: Rrn3 (phospho-S649) polyclonal antibody detects endogenous levels of Rrn3 protein only when phosphorylated at Ser649.

Immunogen:
Synthetic phosphopeptide derived from human Rrn3 around the phosphorylation site of Serine 649

MW: ~ 74 kDa

Swiss-Prot: Q9NYV6

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.