RSPO1 Blocking Peptide (C-Term)

Background:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Other Names:
R-spondin-1, Roof plate-specific spondin-1, hRspo1, RSPO1

Target/Specificity:
The synthetic peptide sequence is selected from aa 226-240 of HUMAN RSPO1

Gene Name: RSPO1

Gene ID: 284654
Primary Accession: Q2MKA7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.