RSPO1 (clone 7A6), anti-human
€478.00
In stock
SKU
252858
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
RSPO1 (R-spondin 1) is a member of the R-spondin family, a 28.9 kDa secreted activator protein. It has two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Alternate Names: R-spondin-1, Roof plate-specific spondin-1, hRspo1, RSPO1
Application Notes: WB: 1:500-1:2000
Accession No.: Q2MKA7
Antigen: Purified recombinant fragment of RSPO1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death
Description:
RSPO1 (R-spondin 1) is a member of the R-spondin family, a 28.9 kDa secreted activator protein. It has two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Alternate Names: R-spondin-1, Roof plate-specific spondin-1, hRspo1, RSPO1
Application Notes: WB: 1:500-1:2000
Accession No.: Q2MKA7
Antigen: Purified recombinant fragment of RSPO1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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