RUNX3 (clone 2B3), anti-human, mouse

Background:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: AML2, CBFA3, PEBP2aC, FLJ34510, MGC16070

Immunogen: Purified recombinant fragment of human RUNX3 (AA:186-252) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage