RUVBL1 monoclonal, anti-human
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In stock
SKU
AC-AM2039b
Catalog Number: AC-AM2039b
Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 507CT2.2.2
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 507CT2.2.2
Applications: WB
Datasheet
Request Information
Background:
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.May be able to bind plasminogen at cell surface and enhance plasminogen activation.Essential for cell proliferation.
Other Names:
RuvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, INO80 complex subunit H, Nuclear matrix protein 238, NMP 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha, TAP54-alpha, RUVBL1, INO80H, NMP238, TIP49, TIP49A
Target/Specificity:
Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: RUVBL1 (HGNC:10474)
Gene ID: 8607
Primary Accession: Q9Y265
NCBI Accession: NP_003698.1
Other Accession: NP_003698.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.May be able to bind plasminogen at cell surface and enhance plasminogen activation.Essential for cell proliferation.
Other Names:
RuvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, INO80 complex subunit H, Nuclear matrix protein 238, NMP 238, Pontin 52, TIP49a, TIP60-associated protein 54-alpha, TAP54-alpha, RUVBL1, INO80H, NMP238, TIP49, TIP49A
Target/Specificity:
Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: RUVBL1 (HGNC:10474)
Gene ID: 8607
Primary Accession: Q9Y265
NCBI Accession: NP_003698.1
Other Accession: NP_003698.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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