S100A4 Monoclonal Antibody

Background:
S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.

Research Area: Cancer, Cardiovascular, Signal Transduction

Synonyms:
18A2, 42A, calcium Placental protein, Calvasculin, CAPL, Fibroblast specific protein 1 (FSP1), Fibroblast specific protein 1, Fibroblast specific protein, FSP1, Leukemia multidrug resistance associated protein, Malignant transformation suppression 1 (MTS1), Malignant transformation suppression 1, Metastasin, MTS1, OTTHUMP00000015467, OTTHUMP00000015468, P9KA, PEL98, Placental calcium-binding protein, Protein Mts1, Protein S100 A4, Protein S100-A4, S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), S100 calcium binding protein A4, S100 calcium-binding protein A4, S100a4, S10A4

Immunogen: Recombinant protein corresponding to Mouse S100A4

Swissprot: P26447,P07091,P05942

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: IHC 1:200-1:800

Storage:
Store at -20°C. Avoid freeze / thaw cycles.