S100A6 [clone EP313], anti-human

Description: S100A6, also known as Calcyclin, is a low molecular weight calcium binding protein encoded near the cluster of S100 family genes on chromosome 1. The S100 family of proteins are structurally related and share Ca2+ binding domains. Monomers of S100A6 can bind 2 Ca2+, but can form homodimers in a Ca2+-independent manner. S100A6 is a cytoplasmic and nuclear protein, associating with the plasma membrane and the nuclear envelope in the presence of Ca2+. It is abundantly expressed in fibroblasts and epithelial cells. It is also detected in some neurons, glial cells, smooth muscle, myocytes, and lymphocytes. S100A6 has been studied in many human tumors, including pancreatic, melanocytic, gastric, and colorectal cancers. In pancreatic cancer, elevation of S100A6 RNA and protein was observed in malignant cells. Nuclear S100A6 expression is associated with reduced survival time in pancreatic cancer patients. S100A6 expression was also significantly correlated with melanoma metastases and survival times. It was upregulated in 50% of gastric cancers, and highly expressed at the invasive margins of colorectal carcinoma.Localization: nucleus, cytoplasmDilution: 50-200Positive Control: colon, colon carcinomaHIER: citrate pH6.0 or EDTA pH8.0Status: RUO