S100A8/MRP8 [clone EP90], anti-human

Description: Myeloid Related Protein 8 (MRP8), also known as S100A8, is a calcium binding protein that belongs to the S100 family. By a Ca2+ dependent manner, S100A8/A9 forms Calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and expressed on the membrane of monocytes. S100A8 is expressed during myeloid differentiation and chronic inflammations, and it is expressed constitutively or induced in epithelial cells during dermatose. MRP8 is expressed in cells with myeloid origin, including granulocytes, monocytes and macrophages, and it is observed in blood granulocytes and monocytes. It is also expressed in infiltrate macrophages during inflammatory reactions, but not in normal tissue macrophages. MRP8 also reacts with activated microglial cells in human cerebral malaria. In tumors, positive staining of MRP8 has been observed in various cancers including pancreatic cancer, and it has been linked to inflammation-associated cancers.Localization: cytoplasm, membraneDilution: 50-200Positive Control: spleenHIER: citrate pH6.0Status: RUO