S100BB (Detection Ab) (clone 1C3), anti-human

Background:
-S100B (S100 calcium binding protein B) is a glial-derived protein that is a well-established biomarker for severity of neurological injury and prognosis for recovery. It functions as a neurotrophic factor and neuronal survival protein during development of the central nervous system. S100B is glial-specific and is expressed at high levels in brain primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells. The increased S100B in the brain can be detrimental and may augment pathogenic responses to injury by accelerating neuroinflammatory processes. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. And the regulation of S100B by melittin has potential for the treatment of epilepsy.-----

Matched antibody pair: -CaptureAb: S100BB mAb (clone # 6H4), Detection Ab: S100BB mAb (clone #1C3)-

Recommended Application:
-ELISA; Lateral flowassay (rapid test)-

Product Form: -Liquid-

Purification & Buffer: -Each vial contains 0.01 M PBS (pH 7.4 ± 0.2) without preservative.-

Purity: ->90% by HPLC & SDS-PAGE-

Storage Instruction:
-Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.