Cleaved-Notch 2 (A1734) polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP63143
Catalog Number: AC-AP72402
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IF
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IF
Datasheet
Request Information
Background:
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL- induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Other Names:
NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
Antigen Type: synthetic peptide
Antigen Type: NOTCH2 (HGNC:7882)
Gene ID: 4853
Primary Accession: Q04721
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL- induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Other Names:
NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
Antigen Type: synthetic peptide
Antigen Type: NOTCH2 (HGNC:7882)
Gene ID: 4853
Primary Accession: Q04721
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