SCN11A antibody (clone 60), anti-human
€435.00
In stock
SKU
AC-AT3791a
Catalog Number: AC-AT3791a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT3791a">Request Information
Background:
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Other Names:
Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, PN5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav19, hNaN, SCN11A, SCN12A, SNS2
Antigen Type:
Recombinant Protein
Gene Name: SCN11A (HGNC:10583)
Gene ID: 11280
NCBI Accession: NP_054858.2
Primary Accession: Q9UI33
Other Accession: NM_014139
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Other Names:
Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, PN5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav19, hNaN, SCN11A, SCN12A, SNS2
Antigen Type:
Recombinant Protein
Gene Name: SCN11A (HGNC:10583)
Gene ID: 11280
NCBI Accession: NP_054858.2
Primary Accession: Q9UI33
Other Accession: NM_014139
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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