SCN8A polyclonal, anti-human, mouse, rat

Background:
The sodium channel protein type 8 subunit alpha (Na+ CP type VIIIα ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disulfide-linked β2 subunit. The two β subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.

Alternative Name:
Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha, Nav1.6, SCN8A, MED

Application Dilution: WB: 1:500~1:1000

Specificity: SCN8A polyclonal antibody detects endogenous levels of SCN8A protein.

Immunogen:
A synthetic peptide corresponding to residues in Human SCN8A

MW: ~ 225 kDa

Swis Prot.: Q9UQD0

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.