SCRATCH1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2052a
Background:
Human SCRT cDNA encodes a protein of 348 amino acids expressed predominantly in the brain and spinal cord, but also in retina and in neuroendocrine cells of the lung. SCRT expression by RT-PCR is observed in lung cancers with neuroendocrine features. This protein holds in common with other Snail family members the ability to bind to E-box enhancer motifs, which are targets of basic helix-loop-helix (bHLH) transcription factors. SCRT impairs heterodimeric proneural bHLH protein achaete-scute homolog-1 and E12, leading to active transcriptional repression at E-box motifs. SCRT has been postulated to function in newly differentiating, postmitotic neurons and in cancers with neuroendocrine features by modulating the action of bHLH transcription factors pivotal to neuronal differentiation.
Other Names:
Transcriptional repressor scratch 1, Scratch homolog 1 zinc finger protein, SCRT, Scratch 1, hScrt, SCRT1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2052a was selected from the C-term region of human SCRATCH1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SCRT1
Gene ID: 83482
Primary Accession: Q9BWW7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Human SCRT cDNA encodes a protein of 348 amino acids expressed predominantly in the brain and spinal cord, but also in retina and in neuroendocrine cells of the lung. SCRT expression by RT-PCR is observed in lung cancers with neuroendocrine features. This protein holds in common with other Snail family members the ability to bind to E-box enhancer motifs, which are targets of basic helix-loop-helix (bHLH) transcription factors. SCRT impairs heterodimeric proneural bHLH protein achaete-scute homolog-1 and E12, leading to active transcriptional repression at E-box motifs. SCRT has been postulated to function in newly differentiating, postmitotic neurons and in cancers with neuroendocrine features by modulating the action of bHLH transcription factors pivotal to neuronal differentiation.
Other Names:
Transcriptional repressor scratch 1, Scratch homolog 1 zinc finger protein, SCRT, Scratch 1, hScrt, SCRT1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2052a was selected from the C-term region of human SCRATCH1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SCRT1
Gene ID: 83482
Primary Accession: Q9BWW7
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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