Human CCL3 Elisa Kit
€0.00
In stock
SKU
SEKH-0246
Catalog Number: SEKH-0246
Detection Range: 31.2-2,000 pg/ml
Sensitivity: 15 pg/ml
Request Manual
Questions? Contact us!
Detection Range: 31.2-2,000 pg/ml
Sensitivity: 15 pg/ml
Request Manual
Questions? Contact us!
Background:
MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils. The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
Long Name: Chemokine (C-C motif) ligand 3
Synonyms:
CCL3, MIP1-A, MIP1A, MIP-1-alpha, SCYA3, G0S19-1, LD78ALPHA, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a, Tonsillar Lymphocyte LD78 Alpha Protein
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 3.5h
MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils. The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
Long Name: Chemokine (C-C motif) ligand 3
Synonyms:
CCL3, MIP1-A, MIP1A, MIP-1-alpha, SCYA3, G0S19-1, LD78ALPHA, Chemokine C-C-Motif Ligand 3, Small Inducible Cytokine A3, Homologous To Mouse Mip-1a, Tonsillar Lymphocyte LD78 Alpha Protein
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 3.5h
| Is Featured? | No |
|---|
Write Your Own Review