Human Perforin Elisa Kit

Background:
Perforin is a pore forming, cytolytic protein that is a component of cytolytic T-cell and NK cell granules. Perforin activates clathrin- and dynamin-dependent endocytosis, which removes perforin and granzymes from the plasm membrane to early endosomes, preserving outer membrane integrity. Perforin facilitates granzyme uptake and avoids the proinflammatory necrotic death of a membrane-damaged cell. Defects in the Perforin gene results in Familial hemophagocytic lymphohistiocytosis (FHL). Perforin-based effector systems are involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation.

Long Name: Perforin 1 (Pore Forming Protein)

Synonyms:
PRF1, FLH2, HPLH2, P1, PFN1, PFP, perforin 1,

Sample Type:
Serum, Plasma, Cell culture supernatant.

Assay Lenght: 3.5h