Human PRLR Elisa Kit

Background:
The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor. Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region. The PRLR also binds and is activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin.The PRLR is a cytokine receptor and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,Ras-Raf-MAPK, and PI3K/AKT/mTOR pathway.The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

Long Name: Prolactin Receptor

Synonyms:
PRLR, PRL-R, Prolactin R,

Sample Type:
Serum, Plasma, Cell culture supernatant.

Assay Lenght: 3.5h