Human TIMP-4 Elisa Kit
€0.00
In stock
SKU
SEKH-0325
Catalog Number: SEKH-0325
Detection Range: 62.5-4,000 pg/ml
Sensitivity: 30 pg/ml
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Detection Range: 62.5-4,000 pg/ml
Sensitivity: 30 pg/ml
Request Manual
Questions? Contact us!
Background:
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Long Name: Tissue Inhibitors of Metalloproteinases 4
Synonyms:
TIMP4, TIMP-4
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 3.5h
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Long Name: Tissue Inhibitors of Metalloproteinases 4
Synonyms:
TIMP4, TIMP-4
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 3.5h
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