Human IL-18RAP / IL1R7 Elisa Kit

Background:
IL‑18 R alpha by itself binds IL-18 with low-affinity and IL-18 R beta does not bind IL-18 in vitro, co-expression of IL-18 R alpha and IL-18 R beta is required for high-affinity binding and IL-18 responsiveness. Human IL-18 R beta cDNA encodes a 599 amino acid (aa) residue precursor type I membrane protein with a 14 aa signal peptide, a 342 aa extracellular region containing three immunoglobulin-like domains, a single transmembrane domain and a 222 aa cytoplasmic domain. Human and mouse IL-18 R beta share 65% aa sequence identity. The expression of IL-18 R beta parallels that of IL-18 R alpha and is detected in numerous tissues including lung, spleen, leukocytes and colon.

Long Name: IL-18 receptor accessory protein;

Synonyms:
Accessory protein-like, AcPL, CD218 antigen-like family member B, CD218b antigen, CD218b, CDw218b, IL-1 R7, IL-18 R beta, IL-18 receptor accessory protein, IL-18 receptor beta, IL18R beta, IL-18RAcP, IL18RAP, IL18RB, IL-18Rb, IL-18Rbeta, IL-18R-beta, IL-1R accessory protein-like, IL1R7, IL-1R7, IL-1R-7, IL-1RAcPL, interleukin 18 receptor accessory protein, Interleukin-1 receptor 7, interleukin-18 receptor accessory protein, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, MGC120589, MGC120590

Sample Type:
Serum, Plasma, Cell culture supernatant.

Assay Lenght: 3.5h