Rabit MMP-12 Elisa Kit
€0.00
In stock
SKU
SEKRT-0148
Catalog Number: SEKRT-0148
Detection Range: 25-1600 pg/ml
Sensitivity: 5 pg/ml
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Detection Range: 25-1600 pg/ml
Sensitivity: 5 pg/ml
Request Manual
Questions? Contact us!
Background:
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-12 (macrophage elastase) is found in macrophages and its expression in monocytes can be induced by cytokines such as GM-CSF and CD40 signaling. In addition to elastin, MMP-12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. It can also activate MMP-2 and MMP-3. MMP-12 is required for macrophage-mediated proteolysis and matrix invasion in mice. MMP-12 is proposed to have a direct role in the pathogenesis of aortic aneurysms and in the development of pulmonary emphysema that results from chronic inhalation of cigarette smoke. Structurally, the pro-MMP-12 consists of following domains: a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin-like domain. The recombinant mouse MMP-12 corresponds to the pro form that can be activated.
Long Name: Matrix Metalloproteinase 12
Synonyms:
MMP12, MMP-12, MME, HME, ME, Macrophage Metalloelastase, Macrophage Elastase, Matrix metallopeptidase 12
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 2-2.5h
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-12 (macrophage elastase) is found in macrophages and its expression in monocytes can be induced by cytokines such as GM-CSF and CD40 signaling. In addition to elastin, MMP-12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. It can also activate MMP-2 and MMP-3. MMP-12 is required for macrophage-mediated proteolysis and matrix invasion in mice. MMP-12 is proposed to have a direct role in the pathogenesis of aortic aneurysms and in the development of pulmonary emphysema that results from chronic inhalation of cigarette smoke. Structurally, the pro-MMP-12 consists of following domains: a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin-like domain. The recombinant mouse MMP-12 corresponds to the pro form that can be activated.
Long Name: Matrix Metalloproteinase 12
Synonyms:
MMP12, MMP-12, MME, HME, ME, Macrophage Metalloelastase, Macrophage Elastase, Matrix metallopeptidase 12
Sample Type:
Serum, Plasma, Cell culture supernatant.
Assay Lenght: 2-2.5h
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