Semaphorin-3 and Neuropilin Antibody Sampler Kit

Background:
One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI-anchored extracellular molecules that have been implicated in neuron development, vascular disease, and tumor progression. There are eight classes of semaphorin genes, all of which are characterized by a conserved 500 amino acid, cystine-rich Sema domain. Sema-3A and Sema-3F are class III secreted semaphorins that bind with high affinity to Neuropilin-1 and Neuropilin-2, respectively. Both Sema-3A and Sema-3F, as well as their neuropilin receptors, may have important roles in axon guidance, angiogenesis, and tumor progression.

Buffer/Storage:
Mouse monoclonal and rabbit polyclonal antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide. Store all at –20°C. Stable for 1 year.