Septin 2 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS8493
Background:
The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTPbinding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGF β signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGF β or, to a lesser extent, by other apoptotic agents. ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs.
Alternative Name:
DIFF6, hNEDD5, KIAA0158, Neural precursor cell expressed developmentally down regulated protein 5, Pnutl3, Protein NEDD5, SEPT2
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: Septin 2 polyclonal antibody detects endogenous levels of Septin 2 protein.
Immunogen:
Recombinant full length Human Septin 2.
MW: ~ 41kDa
Swis Prot.: Q15019
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTPbinding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGF β signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGF β or, to a lesser extent, by other apoptotic agents. ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs.
Alternative Name:
DIFF6, hNEDD5, KIAA0158, Neural precursor cell expressed developmentally down regulated protein 5, Pnutl3, Protein NEDD5, SEPT2
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: Septin 2 polyclonal antibody detects endogenous levels of Septin 2 protein.
Immunogen:
Recombinant full length Human Septin 2.
MW: ~ 41kDa
Swis Prot.: Q15019
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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