E2F-6 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP69629
Background:
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Other Names:
E2F6; Transcription factor E2F6; E2F-6
Antigen Type: synthetic peptide
Antigen Type: E2F6 {ECO:0000303|PubMed:9689056, ECO:0000312|HGNC:HGNC:3120}
Gene ID: 1876
Primary Accession: O75461
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Other Names:
E2F6; Transcription factor E2F6; E2F-6
Antigen Type: synthetic peptide
Antigen Type: E2F6 {ECO:0000303|PubMed:9689056, ECO:0000312|HGNC:HGNC:3120}
Gene ID: 1876
Primary Accession: O75461
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