MLKL polyclonal, anti-human
€470.00
In stock
SKU
AC-AP70971
Background:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Other Names:
MLKL; Mixed lineage kinase domain-like protein
Antigen Type: synthetic peptide
Antigen Type: MLKL {ECO:0000303|PubMed:22265413, ECO:0000312|HGNC:HGNC:26617}
Gene ID: 197259
Primary Accession: Q8NB16
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Other Names:
MLKL; Mixed lineage kinase domain-like protein
Antigen Type: synthetic peptide
Antigen Type: MLKL {ECO:0000303|PubMed:22265413, ECO:0000312|HGNC:HGNC:26617}
Gene ID: 197259
Primary Accession: Q8NB16
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