SERPINB8 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP20066b
Background:
The superfamily of high molecular weight serine proteinaseinhibitors (serpins) regulate a diverse set of intracellular andextracellular processes such as complement activation,fibrinolysis, coagulation, cellular differentiation, tumorsuppression, apoptosis, and cell migration. Serpins arecharacterized by well-conserved a tertiary structure that consistsof 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989[PubMed 2690952]). A critical portion of the molecule, the reactivecenter loop connects beta sheets A and C. Protease inhibitor-8(PI8; SERPINB8) is a member of the ov-serpin subfamily, which,relative to the archetypal serpin PI1 (MIM 107400), ischaracterized by a high degree of homology to chicken ovalbumin,lack of N- and C-terminal extensions, absence of a signal peptide,and a serine rather than an asparagine residue at the penultimateposition (summary by Bartuski et al., 1997 [PubMed9268635]).
Other Names:
Serpin B8, Cytoplasmic antiproteinase 2, CAP-2, CAP2, Peptidase inhibitor 8, PI-8, SERPINB8, PI8
Target/Specificity:
The synthetic peptide sequence is selected from aa 289-301 of HUMAN SERPINB8
Gene Name: SERPINB8
Gene ID: 5271
Primary Accession: P50452
Other Accession: NP_002631.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The superfamily of high molecular weight serine proteinaseinhibitors (serpins) regulate a diverse set of intracellular andextracellular processes such as complement activation,fibrinolysis, coagulation, cellular differentiation, tumorsuppression, apoptosis, and cell migration. Serpins arecharacterized by well-conserved a tertiary structure that consistsof 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989[PubMed 2690952]). A critical portion of the molecule, the reactivecenter loop connects beta sheets A and C. Protease inhibitor-8(PI8; SERPINB8) is a member of the ov-serpin subfamily, which,relative to the archetypal serpin PI1 (MIM 107400), ischaracterized by a high degree of homology to chicken ovalbumin,lack of N- and C-terminal extensions, absence of a signal peptide,and a serine rather than an asparagine residue at the penultimateposition (summary by Bartuski et al., 1997 [PubMed9268635]).
Other Names:
Serpin B8, Cytoplasmic antiproteinase 2, CAP-2, CAP2, Peptidase inhibitor 8, PI-8, SERPINB8, PI8
Target/Specificity:
The synthetic peptide sequence is selected from aa 289-301 of HUMAN SERPINB8
Gene Name: SERPINB8
Gene ID: 5271
Primary Accession: P50452
Other Accession: NP_002631.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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